Magnesium Hydroxide

Abbasi, B., Kimiagar, M., Sadeghniiat, K., Shirazi, M., Hedayati, M., & Rashidkhani, B. (2012). The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences, 17, 1161 - 1169.

Many adults have trouble sleeping, which is called insomnia. This can be because of changes in their bodies and lifestyles as they age. Scientists wanted to see if taking magnesium, a natural substance that helps regulate sleep, could help improve insomnia in adults.

They did a study with 46 elderly participants. Some of them took magnesium supplements, while others took a placebo. They did this for 8 weeks and asked the participants to fill out questionnaires about their sleep and daily activities. They also took blood samples to check certain substances related to sleep.

After the study, they found that the group taking magnesium had better sleep. They slept longer, fell asleep faster, and woke up less during the night. They also had more of certain substances in their blood that help with sleep. The magnesium group felt better overall about their sleep compared to the placebo group.

In conclusion, taking magnesium supplements helps people with insomnia. It can make their sleep better and improve how they feel in the morning.

Wienecke, E., & Nolden, C. (2016). [Long-term HRV analysis shows stress reduction by magnesium intake].. MMW Fortschritte der Medizin, 158 Suppl 6, 12-16 . https://doi.org/10.1007/s15006-016-9054-7.

This study looked at how magnesium, a mineral found in certain foods, can help people when they feel stressed or under mental pressure. They measured something called heart rate variability (HRV), which gives information about how our body's nervous system is working. A low HRV means we might be too stressed. They did a study with 100 participants over 90 days. Some of them took 400 mg of magnesium every day, and others didn't.

The results showed that the group taking magnesium had positive changes in their HRV. It means their body's nervous system was more balanced, and they had less stress. Their body's ability to adapt and recover improved too. The study suggests that taking magnesium daily can help people when they feel stressed and might prevent problems like restlessness, trouble concentrating, and sleep issues.

In conclusion, taking magnesium as a supplement might be helpful for people who experience mental and physical stress. It can improve how our body handles stress and might prevent certain health problems.

Boyle, N., Lawton, C., & Dye, L. (2017). The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients, 9. https://doi.org/10.3390/nu9050429.

Anxiety is a common problem for many people, and some studies suggest that magnesium, a mineral found in certain foods, could help reduce anxiety. Researchers looked at 18 studies to see if magnesium supplements could make people feel less anxious. They focused on groups of people who were already prone to anxiety, like those with mild anxiety, premenstrual syndrome, postpartum status, or hypertension (high blood pressure).

They found that some studies showed positive effects of magnesium on reducing anxiety in these groups.

In conclusion, there is some evidence that magnesium supplements help to reduce anxiety, especially in people who are already prone to anxiety.

Jacka, F., Overland, S., Stewart, R., Tell, G., Bjelland, I., & Mykletun, A. (2009). Association Between Magnesium Intake and Depression and Anxiety in Community-Dwelling Adults: The Hordaland Health Study. Australian and New Zealand Journal of Psychiatry, 43, 45 - 52. https://doi.org/10.1080/00048670802534408.

This study looked at whether eating foods with magnesium could be connected to feeling less depressed and anxious. They studied a large group of adults aged 46-49 and 70-74 years. The participants answered questions about their feelings of depression and anxiety, and they also reported what foods they ate to estimate their magnesium intake.

The results showed that people who ate more magnesium-rich foods tended to have lower depression scores. Even after considering other factors like age and lifestyle, the connection was still there.

In conclusion, this study suggests that eating foods with more magnesium might be connected to feeling less depressed in the community.

Fuentes, J., Salmon, A., & Silver, M. (2006). Acute and chronic oral magnesium supplementation: effects on endothelial function, exercise capacity, and quality of life in patients with symptomatic heart failure.. Congestive heart failure, 12 1, 9-13 . https://doi.org/10.1111/J.1527-5299.2006.04692.X.

Endothelial dysfunction is an important pathophysiologic mechanism in the progression of heart failure. The objective of the present study was to determine the effects of acute and chronic oral magnesium supplementation on endothelial function in patients with symptomatic heart failure. Twenty-two symptomatic chronic heart failure patients were randomized to receive 800 mg oral magnesium oxide daily or placebo for 3 months. Data collected included large and small arterial elasticity/compliance, hemodynamic parameters, exercise capacity, and quality-of-life score at baseline, 1 week, and 3 months. Patients who received magnesium had improved small arterial compliance at 3 months from baseline compared with placebo. This study suggests that chronic supplementation with oral magnesium is well tolerated and could improve endothelial function in symptomatic heart failure patients.

Ince, C., Schulman, S., Quigley, J., Berger, R., Kolasa, M., Ferguson, R., Silver, B., & Haigney, M. (2001). Usefulness of magnesium sulfate in stabilizing cardiac repolarization in heart failure secondary to ischemic cardiomyopathy.. The American journal of cardiology, 88 3, 224-9 . https://doi.org/10.1016/S0002-9149(01)01630-7.

This study looked at how giving patients with heart problems a medicine called magnesium sulfate could help stabilize their hearts. When people have heart failure, they might lose magnesium in their hearts, which can cause irregular heartbeats. The researchers wanted to see if giving magnesium through a slow infusion could make the heartbeats more stable.

They did the study with 15 patients who had heart failure. Some of them received the magnesium treatment, and the others got a fake treatment (placebo) that doesn't do anything. They measured the patients' heartbeats before and after the treatment.

The results showed that the patients who got the magnesium treatment had more stable heartbeats. The medicine helped their hearts work better. It suggests that using magnesium therapy could be helpful for people with heart failure and might reduce the risk of dangerous heart rhythms.

In conclusion, giving patients with heart failure magnesium sulfate through a slow infusion might stabilize their heartbeats and improve their heart health.

Derom, M., Sayón-Orea, C., Martínez-Ortega, J., & Martínez-González, M. (2013). Magnesium and depression: a systematic review. Nutritional Neuroscience, 16, 191 - 206. https://doi.org/10.1179/1476830512Y.0000000044.

This study looked at whether magnesium could be helpful for preventing and treating depression. They reviewed different research studies to see if there is a connection between magnesium and depression in humans.

The results showed that people who eat more magnesium-rich foods might have fewer depression symptoms.

The researchers think that magnesium might be helpful in treating depression, but they need more research to be sure. They suggest that taking magnesium supplements might prevent depression and could be used along with other treatments.

In conclusion, magnesium could have a role in preventing and treating depression.

Tarleton, E., Littenberg, B., MacLean, C., Kennedy, A., & Daley, C. (2017). Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS ONE, 12. https://doi.org/10.1371/journal.pone.0180067.

This study tested whether taking magnesium supplements could help improve symptoms of depression. They did a trial with 126 adults who had mild-to-moderate depression. Half of them took magnesium supplements for 6 weeks, and the other half didn't take anything (control group).

The results showed that those who took magnesium had a significant improvement in their depression symptoms. They felt better after 6 weeks of taking the supplements. The magnesium supplements were safe and well-tolerated, and most participants said they would use magnesium again in the future.

In conclusion, taking magnesium supplements might be helpful for people with mild-to-moderate depression. It can work quickly and is safe to use without any major side effects.

Eby, G., & Eby, K. (2010). Magnesium for treatment-resistant depression: a review and hypothesis.. Medical hypotheses, 74 4, 649-60 . https://doi.org/10.1016/j.mehy.2009.10.051.

Many cases of depression do not get better with usual treatments, and this is called treatment-resistant depression (TRD). One reason for this might be not having enough magnesium in the body. Magnesium is important for our brain's health, and not having enough can lead to depression.

Scientists have done studies with animals and found that giving them magnesium makes them less depressed. Some studies in people also showed that low magnesium levels are connected to severe depression and suicidal thoughts. Giving magnesium to people with depression has shown promising.

In the past, magnesium was used to treat depression successfully in many people, but over time, it was taken out of our food. Some food additives like calcium, glutamate, and aspartate might also make depression worse.

Based on all this information, the researchers suggest that taking magnesium supplements could be a helpful treatment for depression, especially for those with TRD. They also think that magnesium might be beneficial for all people with depression, not just those with TRD. Magnesium seems to play a crucial role in our mental health and could be a valuable addition to depression treatment.

Serefko, A., Szopa, A., & Poleszak, E. (2016). Magnesium and depression.. Magnesium research, 29 3, 112-119 . https://doi.org/10.1684/MRH.2016.0407.

Magnesium is a very important element in our bodies, and it helps with many processes in our heart, digestion, hormones, bones, and brain. When we don't have enough magnesium, it can cause changes in our mood, like feeling sad, anxious, or confused.

In studies with animals, they found that when they didn't give them enough magnesium in their diet, they became depressed. But when they gave them medicine for depression, it helped them feel better.

Sometimes, our body doesn't get enough magnesium because of poor diet, certain diseases, stress, or medications we take. It's not easy to measure the exact amount of magnesium in our body.

Scientists have done many studies with magnesium supplements, and they found that it can improve our mood and work well with other depression treatments. However, the type of magnesium we take can affect how well our body absorbs it.

In conclusion, magnesium is important for our bodies, and when we don't have enough, it can lead to changes in our mood. Taking magnesium supplements might be helpful for people with depression and could work well with other treatments.

Rajizadeh, A., Mozaffari‐khosravi, H., Yassini-Ardakani, M., & Dehghani, A. (2017). Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: A randomized, double-blind, placebo-controlled trial.. Nutrition, 35, 56-60 . https://doi.org/10.1016/j.nut.2016.10.014.

The researchers wanted to see if taking magnesium supplements can help people with depression who also have low levels of magnesium in their body. They studied 60 depressed people who had low magnesium levels. They split them into two groups, with one group taking magnesium supplements every day, and the other group taking fake pills (placebo).

After 8 weeks, they found that 88.5% of the people who took magnesium supplements had their magnesium levels return to normal, while only 48.1% in the placebo group did. The people taking magnesium supplements also showed more significant improvements in their depression symptoms compared to the placebo group.

In conclusion, taking 500 mg magnesium oxide tablets every day for at least 8 weeks can help improve depression and magnesium levels in people with low magnesium.

Sun, C., Wang, R., Li, Z., & Zhang, D. (2019). Dietary magnesium intake and risk of depression.. Journal of affective disorders, 246, 627-632 . https://doi.org/10.1016/j.jad.2018.12.114.

This study looked at how the amount of magnesium in our diet is connected to the risk of depression. They studied a large group of adults and asked them about their diet and feelings of depression.

The results showed that people who had more magnesium in their diet had a lower risk of depression. This means that eating foods with magnesium might help reduce the chances of feeling depressed. This was especially true for women and people of all ages.

In conclusion, eating foods with magnesium is helpful in lowering the risk of depression, but we need more studies to be certain.

Botturi, A., Ciappolino, V., Delvecchio, G., Boscutti, A., Viscardi, B., & Brambilla, P. (2020). The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients, 12. https://doi.org/10.3390/nu12061661.

Magnesium is an essential cation involved in many functions within the central nervous system, including transmission and intracellular signal transduction. Several studies have shown its usefulness in neurological and psychiatric diseases. Furthermore, it seems that magnesium levels are lowered in the course of several mental disorders, especially depression. In this study, they evaluated the presence of a relationship between the levels of magnesium and the presence of psychiatric pathology as well as the effectiveness of magnesium as a therapeutic supplementation. A systematic search of scientific records concerning magnesium in psychiatric disorders published from 2010 up to March 2020 was performed. They collected a total of 32 articles: 18 on Depressive Disorders (DD), four on Anxiety Disorders (AD), four on Attention Deficit Hyperactivity Disorder (ADHD), three on Autism Spectrum Disorder (ASD), one on Obsessive–Compulsive Disorder (OCD), one on Schizophrenia (SCZ) and one on Eating Disorders (ED). Twelve studies highlighted mainly positive results in depressive symptoms. Seven showed a significant correlation between reduced plasma magnesium values and depression measured with psychometric scales. Two papers reported improved depressive symptoms after magnesium intake, two in association with antidepressants, compared to controls. No significant association between magnesium serum levels and panic or Generalized Anxiety Disorder (GAD) patients, in two distinct papers, was found. In two other papers, a reduced Hamilton Anxiety Rating Scale (HAM-A) score in depressed patients correlated with higher levels of magnesium and beneficial levels of magnesium in stressed patients was found. Two papers reported low levels of magnesium in association with ADHD. Only one of three papers showed lower levels of magnesium in ASD. Also, it was reported that a variation in magnesium levels in some aspects of the disease. The results are not univocal, both in terms of the plasma levels and of therapeutic effects. However, from the available evidence, it emerged that supplementation with magnesium could be beneficial.